| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83316-2mg买3赠1 |
99.90% | ￥190.00 |
5 | - | - | - | - |
|
S83316-5mg买3赠1 |
99.90% | ￥260.00 |
2 | - | - | - | - |
|
S83316-10mg买3赠1 |
99.90% | ￥410.00 |
6 | - | - | - | - |
|
S83316-25mg买3赠1 |
99.90% | ￥730.00 |
5 | - | - | - | - |
|
S83316-50mg |
≥98% | ￥1250.00 |
货期：2-3天 | - | - | - | - |
|
S83316-100mg |
≥98% | ￥2000.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | 3-AP (PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer. | ||||||||||||||||||||
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| 靶点： | Ribonucleotide reductase (RR);DNA/RNASynthesis | ||||||||||||||||||||
| 体内研究： | 3-AP (Triapine) causes a significant increase (1.7-fold) in splenic weight when expressed as a percentage of total body weight (1.02±0.06%; n=25) compared with control mice (0.6±0.03%; n=27). In the long-term group, a significant increase in heart weight is observed after Dp44mT (0.4 mg/kg per day) (0.8±0.06%; n=4) compared with control mice (0.5±0.01%; n=6). A significant decrease in the expression of Ndrg1, TfR1, and VEGF1 in the liver is noted for Dp44mT- and 3-AP (12 mg/kg per day)-treated animals. The decreased expression could be related to the increased liver Fe in both Dp44mT- and 3-AP-treated mice | ||||||||||||||||||||
| 参考文献： | 1. Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e475-81. 2. Yalowich JC, et al. The anticancer thiosemicarbazones Dp44mT and Triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα. Biochem Pharmacol. 2012 Jul 1;84(1):52-8. 3. Whitnall M, et al. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 47 mg/mL (240.73 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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