| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83365-5mg |
≥99% | ￥710.00 |
货期：3-5天 | - | - | - | - |
|
S83365-10mg |
≥99% | ￥1120.00 |
货期：3-5天 | - | - | - | - |
|
S83365-50mg |
≥99% | ￥2910.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers. | ||||||||||||||||||||
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| 靶点： | IAP | ||||||||||||||||||||
| 体外研究： | GDC-0917 (0.1 nM-10 μM) induces reduction of cIAP1 levels in PBMCs in a concentration-dependent manner showing greater than 80% inhibition at concentrations greater than 0.1 µM (56.5 ng/mL) | ||||||||||||||||||||
| 体内研究： | GDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg). Oral bioavailability is lowest in monkeys compared with other species | ||||||||||||||||||||
| 参考文献： | 1. Wong H, et al. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. Drug Metab Dispos. 2013 Dec;41(12):2104-13. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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