货号	规格	价格	上海	北京	珠海	重庆	武汉
S83374-100mg促销	97.00%	￥232.00 ￥160.00 S83374-100mg ￥160.00 现货	205 0 >10	-	-	-	-
S83374-250mg促销	97.00%	￥390.00 ￥280.00 S83374-250mg ￥280.00 现货	86 >10	-	-	-	-
S83374-1g促销	97.00%	￥1250.00 ￥890.00 S83374-1g ￥890.00 现货	23 >10	-	-	-	-
S83374-5g促销	≥97%	￥4490.00 ￥3230.00 S83374-5g ￥3230.00 现货	4 4	-	-	-	-

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产品描述：

Protein degrader 1 hydrochloride is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).

靶点：

Ligand for E3 Ligase;Others; LigandforE3Ligase

体外研究：

Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used

参考文献：

1. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.141 ml	10.706 ml	21.412 ml
5 mM	0.428 ml	2.141 ml	4.282 ml
10 mM	0.214 ml	1.071 ml	2.141 ml
50 mM	0.043 ml	0.214 ml	0.428 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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Protein degrader 1 (hydrochloride)