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Protein degrader 1 (hydrochloride)

    
97.00%

Protein degrader 1 (hydrochloride)

源叶(MedMol)
S83374 一键复制产品信息
1448189-80-7
C22H31ClN4O3S
467.02454
(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide hydrochloride; (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S83374-100mg促销
97.00%

¥232.00 ¥160.00

>10 - - - -
S83374-250mg促销
97.00%

¥390.00 ¥280.00

>10 - - - -
S83374-1g促销
97.00%

¥1250.00 ¥890.00

>10 - - - -
S83374-5g促销
≥97%

¥4490.00 ¥3230.00

4 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Protein degrader 1 hydrochloride is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
靶点: Ligand for E3 Ligase;Others; LigandforE3Ligase
体外研究: Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used
参考文献: 1. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.141 ml 10.706 ml 21.412 ml
5 mM 0.428 ml 2.141 ml 4.282 ml
10 mM 0.214 ml 1.071 ml 2.141 ml
50 mM 0.043 ml 0.214 ml 0.428 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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