| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83380-2mg促销 |
95.40% | ￥1050.00 ￥840.00 |
5 | - | - | - | - |
|
S83380-5mg促销 |
95.40% | ￥1620.00 ￥1290.00 |
6 | - | - | - | - |
|
S83380-10mg促销 |
95.40% | ￥2330.00 ￥1860.00 |
6 | - | - | - | - |
|
S83380-25mg促销 |
95.40% | ￥3710.00 ￥2960.00 |
5 | - | - | - | - |
|
| 产品描述： | NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. | ||||||||||||||||||||
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| 靶点： | IC50: 360 nM (Cellular p97, 1 mM ATP), 370 nM (Cellular p97, 60 μM ATP);Others | ||||||||||||||||||||
| 体外研究： | NMS-859 is a potent VCP inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. NMS-859 shows very weak inhibitory activity against VCPC522T. NMS-859 also suppresses the proliferation of cells, with IC50s of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively | ||||||||||||||||||||
| 参考文献： | 1. Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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