| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83391-1mg买3赠1 |
99.90% | ￥170.00 |
5 | - | - | - | - |
|
S83391-2mg买3赠1 |
99.90% | ￥299.00 |
6 | - | - | - | - |
|
S83391-5mg买3赠1 |
99.90% | ￥544.00 |
7 | - | - | - | - |
|
S83391-10mg买3赠1 |
99.90% | ￥986.00 |
7 | - | - | - | - |
|
S83391-25mg买3赠1 |
99.90% | ￥1900.00 |
5 | - | - | - | - |
|
S83391-50mg买3赠1 |
≥98% | ￥3690.00 |
货期：2-3天 | - | - | - | - |
|
S83391-100mg |
≥98% | ￥5720.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | SIRT1：56 μM (IC50)；SIRT2：59 μM (IC50);Apoptosis; Phospholipase; Sirtuin | ||||||||||||||||||||
| 体内研究： | Cambinol is well tolerated in mice (100 mg/kg) and inhibits growth of Burkitt lymphoma xenografts. No significant weight loss occurs in cambinol-treated animals relative to controls. Inhibitors of NAD-dependent deacetylases may constitute novel anticancer agents | ||||||||||||||||||||
| 参考文献： | 1. Heltweg B, et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77. 2. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. | ||||||||||||||||||||
| 溶解性： | DMSO : 50 mg/mL (138.72 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | RT | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京