货号	规格	价格	上海	北京	珠海	重庆	武汉
S83417-1mg买3赠1	99.90%	￥370.00 S83417-1mg ￥370.00 现货（买3赠1）	9 9	-	-	-	-
S83417-5mg买3赠1	99.90%	￥490.00 S83417-5mg ￥490.00 现货（买3赠1）	9 9	-	-	-	-
S83417-10mg	99.90%	￥790.00 S83417-10mg ￥790.00 现货	8 8	-	-	-	-
S83417-50mg	99.90%	￥1920.00 S83417-50mg ￥1920.00 现货	6 6	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

GJ103 sodium salt is an active analog of GJ072, a read-through compound.

靶点：

ATM/ATR

体外研究：

GJ072 induces ATM kinase on both TGA and TAG stop codons and restored ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation as measured by FACS. GJ072 is active in A-T cells with a homozygous TAA mutation. GJ072 is able to induce detectable full-length ATM protein in treated A-T cells. Early structure-activity relationship studies generates eight active analogs of GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and IRIF assays. GJ071 and GJ072 and some of their analogs (such as GJ103) have similar read-through activity as RTC13 or RTC14, but are more tolerable than RTC13 and RTC14 to A-T cells. GJ103 does not show obvious cytotoxicity in A-T cells at concentration as high as 300 μM.

体内研究：

GJ103 sodium salt is water soluble, which will enable us to evaluate its in vivo activity by systematic administration.

参考文献：

1. Du L, et al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.745 ml	13.723 ml	27.446 ml
5 mM	0.549 ml	2.745 ml	5.489 ml
10 mM	0.274 ml	1.372 ml	2.745 ml
50 mM	0.055 ml	0.274 ml	0.549 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

GJ103 (sodium salt)