| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83420-1mg买3赠1 |
99.50% | ￥270.00 |
9 | - | - | - | - |
|
S83420-5mg买3赠1 |
99.50% | ￥690.00 |
5 | - | - | - | - |
|
S83420-10mg买3赠1 |
99.50% | ￥960.00 |
5 | - | - | - | - |
|
S83420-50mg促销 |
99.50% | ￥2170.00 ￥1730.00 |
2 | - | - | - | - |
|
S83420-100mg促销 |
≥99% | ￥3150.00 ￥2520.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | M. tuberculosis;Antibacterial | ||||||||||||||||||||
| 体外研究： | BM212 (2 μg/mL and 8 μg/mL) leads to major structural changes in the cell of M. abscessus CIP104536T S and R variants and results in the complete loss of the hydrophobic nanodomains observed on S cells but no significantly affect on R cells at dose of 2 μg/mL. BM212 (0.5-10 μg/mL, 7 days) inhibits the activity of Mycobacterium avium in U937 cells in a dose-dependent manner with a MIC of 0.5 μg/mL and 100% inhibition starting at a concentration of 1 μg/mL | ||||||||||||||||||||
| 参考文献： | 1. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. 2. Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) 3. Albertus Viljoen, et al. Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria. Nanoscale Horiz. 2020 Jun 1;5(6):944-953. 4. Delia Deidda, et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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