货号	规格	价格	上海	北京	珠海	重庆	武汉
S83551-1mg买3赠1	99.20%	￥320.00 S83551-1mg ￥320.00 现货（买3赠1）	8 8	-	-	-	-
S83551-5mg买3赠1	99.20%	￥570.00 S83551-5mg ￥570.00 现货（买3赠1）	4 4	-	-	-	-
S83551-10mg买3赠1	99.20%	￥1050.00 S83551-10mg ￥1050.00 现货（买3赠1）	6 6	-	-	-	-
S83551-25mg买3赠1	99.20%	￥1970.00 S83551-25mg ￥1970.00 现货（买3赠1）	5 5	-	-	-	-
S83551-50mg买3赠1	≥98%	￥3150.00 S83551-50mg ￥3150.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S83551-100mg买3赠1	≥98%	￥4480.00 S83551-100mg ￥4480.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

ML355是有效的选择性h12-LOX抑制剂，IC50为290 nM

靶点：

12-LOX;Lipoxygenase

体外研究：

ML355 displays nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases

体内研究：

In vivo PK studies where ML355 is administered as a solution via IV (3mpk) and PO (30mpk) demonstrated that ML355 is orally bioavailable (%F = 20) with good half-life (T1/2 = 2.9 hours). At 30 mpk dosing, ML355 achieves a Cmax of over 135 times the in vitro IC50 and remains over IC50 value for over 12 hours. The compound has low clearance (3.4 mL/min/kg) and good overall exposure (AUCinf) of 38 µM. Although, the volume of distribution (VD) observed is low (0.55 L/kg), the rest of the PK profiling results suggest a reasonable distribution between tissue and blood

细胞实验：

Cell lines: U87 cells Concentrations: 10 µM Incubation Time: 24 h Method: Cells were treated with indicated concentration of drug for 24 h.

动物实验：

Animal Models: C57BL/6 mice Dosages: 15 or 30 mg/kg Administration: p.o.

参考文献：

1. Luci D, et al. Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2013 Apr 12 [updated 2014 Sep 18]. 2. Yang X, et al. miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities. Oncogenesis. 2021 Feb 12;10(2):15. 3. Adili R, et al. First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1828-1839.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.265 ml	11.324 ml	22.649 ml
5 mM	0.453 ml	2.265 ml	4.53 ml
10 mM	0.226 ml	1.132 ml	2.265 ml
50 mM	0.045 ml	0.226 ml	0.453 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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