| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83584-2mg买3赠1 |
98.00% | ￥50.00 |
4 | - | - | - | - |
|
S83584-5mg促销 |
98.00% | ￥90.00 ￥72.00 |
6 | - | - | - | - |
|
S83584-10mg促销 |
98.00% | ￥150.00 ￥120.00 |
5 | - | - | - | - |
|
S83584-50mg促销 |
98.00% | ￥400.00 ￥360.00 |
3 | - | - | - | - |
|
S83584-100mg |
≥98% | ￥750.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | 4-IBP是选择性σ1 receptor激动剂，对σ1受体具有高亲和力，Ki值为1.7 nM，而对σ2受体的亲和力较弱，Ki值为25.2 nM | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | σ1 receptor:1.7 nM(Ki); σ2 receptor:25.2 nM(Ki);Sigmareceptor | ||||||||||||||||||||
| 体外研究： | 4-IBP decreases the migration levels of various types of cancer cells, including C32 melanoma, U373-MG glioblastoma, A549 NSCLC, and PC3 prostate cancer cells. 4-IBP modifies the sensitivity of U373-MG cells in vitro to proapoptotic lomustin and proautophagic temozolomide, and markedly decreases the expression of two proteins involved in drug resistance: glucosylceramide synthase and Rho guanine nucleotide dissociation inhibitor | ||||||||||||||||||||
| 体内研究： | In vivo, 4-IBP increases the antitumor effects of temozolomide and irinotecan in immunodeficient mice that are orthotopically grafted with invasive cancer cells | ||||||||||||||||||||
| 参考文献： | 1. Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2007, 9(5):358-69. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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