品牌：源叶(MedMol)

产品编号：S83649 一键复制产品信息

CAS号：158681-13-1

分子式：C₂₂H₂₁Cl₃N₄O.ClH

分子量：500.248

别名：盐酸利莫那班;5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(1-哌啶基)-1H-吡唑-3-甲酰胺盐酸盐;5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(1-哌啶基)-1H-吡唑-3-甲酰胺单盐酸盐;利莫那班盐酸盐;N-(哌啶-1-基)-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-1H-吡唑-3-甲酰胺盐酸盐;利莫那般;利莫那班D10盐酸;RIMONABAN

货号	规格	价格	上海	北京	珠海	重庆	武汉
S83649-10mg买3赠1	98.50%	￥320.00 S83649-10mg ￥320.00 现货（买3赠1）	9 9	-	-	-	-
S83649-50mg促销	98.50%	￥1150.00 ￥920.00 S83649-50mg ￥920.00 现货	9 9	-	-	-	-
S83649-100mg促销	98.50%	￥1910.00 ￥1520.00 S83649-100mg ￥1520.00 现货	12 >10	-	-	-	-

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产品描述：

Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

靶点：

CB1:1.8 nM (Ki);CannabinoidReceptor; Antibacterial

体内研究：

Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant . Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors

参考文献：

1. Seely KA, et al. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct;63(5):905-15. 2. Zhang B, et al. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24;176(3):636-648.e13. 3. Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.

溶解性：

DMSO : 33.33 mg/mL (66.63 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.999 ml	9.995 ml	19.99 ml
5 mM	0.4 ml	1.999 ml	3.998 ml
10 mM	0.2 ml	1 ml	1.999 ml
50 mM	0.04 ml	0.2 ml	0.4 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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Rimonabant hydrochloride