货号	规格	价格	上海	北京	珠海	重庆	武汉
S83669-2mg买3赠1	99.60%	￥200.00 S83669-2mg ￥200.00 现货（买3赠1）	4 4	-	-	-	-
S83669-5mg买3赠1	99.60%	￥260.00 S83669-5mg ￥260.00 现货（买3赠1）	4 4	-	-	-	-
S83669-10mg买3赠1	99.60%	￥300.00 S83669-10mg ￥300.00 现货（买3赠1）	4 4	-	-	-	-
S83669-50mg买3赠1	99.60%	￥890.00 S83669-50mg ￥890.00 现货（买3赠1）	7 7	-	-	-	-
S83669-100mg买3赠1	99.60%	￥1600.00 S83669-100mg ￥1600.00 现货（买3赠1）	6 6	-	-	-	-

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产品描述：

NIBR189 是 Epstein-Barr virus-induced gene 2 (EBI2, GPR183) receptor 的有效拮抗剂，其结合的IC50值为16 nM，其功能的IC50值为11 nM

靶点：

EBI2 (function)(Cell-free assay):11 nM; EBI2 (binding)(Cell-free assay):16 nM;EBI2/GPR183

体外研究：

NIBR189, the EBI2 antagonist, blocks the migration of U937 cells expressing functional EBI2 levels with an IC50 of 0.3 nM

体内研究：

NIBR189 is a potent and selective EBI2 antagonist with pharmacokinetic properties which should allow use for in vitro and in vivo experiments

细胞实验：

Cell lines: U937 cells Concentrations: 20 nM Incubation Time: 3 h Method: Prior to the migration assay, U937 cells were kept overnight in lipid-depleted media. Chemotaxis was performed using HTS Transwell-96 plates with 5.0 μm pore polycarbonate membranes. In brief, lower chambers were filled with 240 μL of compound solution in media in which the FCS was substituted with 1% BSA, and after insertion of the filters, 0.75×105 cells in 75 μL media were added to the upper chamber. After 3 h at 37℃, cells in the lower chamber were analyzed by flow cytometry.

动物实验：

Animal Models: C57BL/6 male mice Dosages: 1 mg/kg (i.v.); 3 mg/kg (p.o.) Administration: i.v., p.o.

参考文献：

1. Francois Gessier, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57(8):3358-68.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.329 ml	11.647 ml	23.293 ml
5 mM	0.466 ml	2.329 ml	4.659 ml
10 mM	0.233 ml	1.165 ml	2.329 ml
50 mM	0.047 ml	0.233 ml	0.466 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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