货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S83670-1mg	≥99%	￥2380.00 S83670-1mg ￥2380.00 3-5天	0 货期：3-5天	-	-	-	-
S83670-5mg	≥99%	￥5980.00 S83670-5mg ￥5980.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK.

靶点：

IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8-36.3 nM (Src), 0.187-0.198 μM (ITK),5.34-4.87 μM (JAK3);Others

体外研究：

Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells

参考文献：

1. Betty Y. CHANG, et al. Companion diagnostics for tec family kinase inhibitor therapy. WO 2014059368 A1.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.911 ml	4.556 ml	9.113 ml
5 mM	0.182 ml	0.911 ml	1.823 ml
10 mM	0.091 ml	0.456 ml	0.911 ml
50 mM	0.018 ml	0.091 ml	0.182 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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