货号	规格	价格	上海	北京	珠海	重庆	武汉
S83704-5mg买3赠1	98.40%	￥80.00 ￥70.00 S83704-5mg ￥70.00 现货（买3赠1）	8 8	-	-	-	-
S83704-10mg买3赠1	98.40%	￥120.00 ￥100.00 S83704-10mg ￥100.00 现货（买3赠1）	6 6	-	-	-	-
S83704-50mg买3赠1	98.40%	￥260.00 S83704-50mg ￥260.00 现货（买3赠1）	3 3	-	-	-	-

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产品描述：

Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa.

靶点：

β-lactam;Antibiotic

体外研究：

Tebipenem exhibits slow tight-binding inhibition at low micromolar concentrations versus the chromogenic substrate nitrocefin, and apparent Km and kcat values of 0.8 μM and 0.03 min-1, respectively. Tebipenem shows potent activity against B. pseudomallei, with MIC50 and MIC90 values of both 2 mg/L. Tebipenem shows good activity against S. pneumoniae, with the MIC range of ≤0.25 μg/mL in all of the S. pneumoniae isolates

参考文献：

1. Hazra S, et al. Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis. Biochemistry. 2014 Jun 10;53(22):3671-8 2. Seenama C, et al. In vitro activity of tebipenem against Burkholderia pseudomallei. Int J Antimicrob Agents. 2013 Oct;42(4):375. 3. Li H, et al. In vitro antibacterial activities of two novel oral antibiotics, tebipenem and cefditoren, and other comparators against community-acquired respiratory tract infection-associated bacterial pathogens: A multicentre study in China. Int J Antimicrob Agents. 2014 Jan;43(1):92-3.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.608 ml	13.038 ml	26.077 ml
5 mM	0.522 ml	2.608 ml	5.215 ml
10 mM	0.261 ml	1.304 ml	2.608 ml
50 mM	0.052 ml	0.261 ml	0.522 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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