货号	规格	价格	上海	北京	珠海	重庆	武汉
S83725-5mg	≥98%	￥240.00 S83725-5mg ￥240.00 现货	7 7	-	-	-	-
S83725-10mg	≥98%	￥410.00 S83725-10mg ￥410.00 现货	5 5	-	-	-	-
S83725-50mg	≥98%	￥1430.00 S83725-50mg ￥1430.00 现货	2 2	-	-	-	-

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产品描述：

XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), but XY1 is completely inactive. Target: PRMT3 XY1 is a close analogue of SGC707, is completely inactive againstPRMT3 at concentrations as high as 100 μM. XY1 contains a naphthyl group replacing the isoquinoline group, lacks the key hydrogen bond with T466. The naphthyl ring of XY1 could act as a weak hydrogen-bond acceptor, but this should come with a substantial enthalpic penalty. The more than 1000-fold potency loss of XY1 compared with SGC707 supports this analysis. It is unclear whether other factors such as electronic effects also contributed to the potency loss of XY1 compared with SGC707. SGC707 and XY1 are a pair of excellent tools for the biomedical community to further elucidate biological functions and disease associations of PRMT3.

靶点：

Histone Methyltransferase;HistoneMethyltransferase

参考文献：

1. Kaniskan H?, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.363 ml	16.815 ml	33.63 ml
5 mM	0.673 ml	3.363 ml	6.726 ml
10 mM	0.336 ml	1.682 ml	3.363 ml
50 mM	0.067 ml	0.336 ml	0.673 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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