货号	规格	价格	上海	北京	珠海	重庆	武汉
S83781-1mg买3赠1	99.14%	￥450.00 S83781-1mg ￥450.00 现货（买3赠1）	104 >10	-	-	-	-
S83781-5mg买3赠1	99.14%	￥900.00 S83781-5mg ￥900.00 现货（买3赠1）	27 >10	-	-	-	-
S83781-10mg买3赠1	99.14%	￥1360.00 S83781-10mg ￥1360.00 现货（买3赠1）	16 >10	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.

靶点：

PPARα:0.65 pM (EC50, HepG2 cell);PPARγ:3 nM (EC50, HepG2 cell);Others

体内研究：

In db/db mice, 12-day treatment with Saroglitazar (0.01-3 mg/kg per day, orally) causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose. A 90-day repeated dose comparative study in Wistar rats and marmosets confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes

参考文献：

1. Jain MR, et al. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering effects in preclinical models. Pharmacol Res Perspect. 2015 Jun;3(3):e00136.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.109 ml	5.547 ml	11.094 ml
5 mM	0.222 ml	1.109 ml	2.219 ml
10 mM	0.111 ml	0.555 ml	1.109 ml
50 mM	0.022 ml	0.111 ml	0.222 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Saroglitazar (Magnesium)