货号	规格	价格	上海	北京	珠海	重庆	武汉
S83782-1mg	≥98%	￥1090.00 S83782-1mg ￥1090.00 3-5天	0 货期：3-5天	-	-	-	-
S83782-5mg	≥98%	￥2840.00 S83782-5mg ￥2840.00 3-5天	0 货期：3-5天	-	-	-	-
S83782-10mg	≥98%	￥3980.00 S83782-10mg ￥3980.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with an IC50 of 0.33 µM.

靶点：

IC50: 0.33 µM (HIPK2);Others

体外研究：

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID, displays toward HIPK2 unprecedented efficacy (IC50=0.33 µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture

参考文献：

1. Cozza G, et al. Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2). PLoS One. 2014 Feb 24;9(2):e89176.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.891 ml	9.456 ml	18.912 ml
5 mM	0.378 ml	1.891 ml	3.782 ml
10 mM	0.189 ml	0.946 ml	1.891 ml
50 mM	0.038 ml	0.189 ml	0.378 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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