货号	规格	价格	上海	北京	珠海	重庆	武汉
S83786-10mg买3赠1	99.90%	￥765.00 S83786-10mg ￥765.00 现货（买3赠1）	6 6	-	-	-	-
S83786-50mg买3赠1	99.90%	￥2970.00 S83786-50mg ￥2970.00 现货（买3赠1）	2 2	-	-	-	-
S83786-100mg买3赠1	≥99%	￥4670.00 S83786-100mg ￥4670.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

6-Iodopravadoline is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.

靶点：

Cannabinoid Receptor;CannabinoidReceptor

体内研究：

6-Iodopravadoline (AM630) (1, 2 or 3 mg/kg, i.p., twice a day) produces a significant anxiolytic effect, increasing the time spent in the light box at all of the doses used[1]. 6-Iodopravadoline (AM630) (2, 3 mg/kg, i.p.) significantly reduces the time spent in the light box, compared with vehicle group.

参考文献：

1.Mukherjee, Sutapa., et al. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European Journal of Pharmacology (2004), 505(1-3), 1-9. 2.Geng, D. C., et al. Inhibition of titanium particle-induced inflammatory osteolysis through inactivation of cannabinoid receptor 2 by AM630. Journal of Biomedical Materials Research, Part A (2010), 95A(1), 321-326. 3.Patil, Mayur., et al. Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology (2011), 61(4), 778-788. 4.Garcia-Gutierrez, Maria S., et al. Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABAA receptors. British Journal of Pharmacology (2012), 165(4), 951-964. 5.Sun L, et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814.

溶解性：

DMSO:50 mg/mL (99.14 mM),Need ultrasonic

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.983 ml	9.914 ml	19.827 ml
5 mM	0.397 ml	1.983 ml	3.965 ml
10 mM	0.198 ml	0.991 ml	1.983 ml
50 mM	0.04 ml	0.198 ml	0.397 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

AM 630