货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S83793-5mg	≥99%	￥1520.00 S83793-5mg ￥1520.00 3-5天	0 货期：3-5天	-	-	-	-
S83793-10mg	≥99%	￥2500.00 S83793-10mg ￥2500.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S83793-5mg

≥99%

￥1520.00

货期：3-5天

S83793-10mg

≥99%

￥2500.00

货期：3-5天

产品描述：

ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions

靶点：

PDE1:58 pM (Ki);PDE1A:33 pM (Ki);PDE1B:380 pM (Ki);PDE1C:35 pM (Ki);PDE

体外研究：

ITI-214 expresses >1000-fold greater activity toward PDE1 isoforms compared with the next nearest PDE family enzyme, PDE4D (Ki= 33 nM) and 10,000-300,000-fold selectivity toward all other PDE enzyme families

体内研究：

ITI-214 significantly enhances memory performance in the test with a minimum effective dose of 3 mg/kg. Animal Model: Male Sprague-Dawley rats Dosage: 0.1-10 mg/kg Administration: p.o. Result: Significantly enhanced memory performance in the test with a minimum effective dose of 3 mg/kg.

参考文献：

1. Li P, et al. Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. J Med Chem. 2016;59(3):1149-1164. 2. Snyder GL, et al. Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats. Psychopharmacology (Berl). 2016;233(17):3113-3124.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.651 ml	8.257 ml	16.514 ml
5 mM	0.33 ml	1.651 ml	3.303 ml
10 mM	0.165 ml	0.826 ml	1.651 ml
50 mM	0.033 ml	0.165 ml	0.33 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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计算重置

ITI214