Ro 25-6981

≥98%

(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE

产品说明书产品使用指南

品牌：源叶(MedMol)

产品编号：S83871 一键复制产品信息

CAS号：169274-78-6

分子式：C₂₆H₃₃NO₆

分子量：455.543

别名：RO 25-6981 MALEATE;(alpha-R,beta-S)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol

货号	规格	价格	上海	北京	珠海	重庆	武汉
S83871-5mg	≥98%	￥810.00 S83871-5mg ￥810.00 3-5天	0 货期：3-5天	-	-	-	-
S83871-10mg	≥98%	￥1130.00 S83871-10mg ￥1130.00 3-5天	0 货期：3-5天	-	-	-	-
S83871-50mg	≥98%	￥2870.00 S83871-50mg ￥2870.00 3-5天	0 货期：3-5天	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD)

靶点：

NMDA Receptor;NMDAR

体内研究：

Ro 25-6981 (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats. Ro 25-6981 (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats. Ro 25-6981 (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia

参考文献：

1. Löschmann PA, et al. Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. Exp Neurol. 2004 May;187(1):86-93. 2. Szczurowska E,et al. Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats. Brain Res Bull. 2015 Feb;111:1-8. 3. Jiang M, et al. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.

溶解性：

Soluble in DMSO

保存条件：

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.195 ml	10.976 ml	21.952 ml
5 mM	0.439 ml	2.195 ml	4.39 ml
10 mM	0.22 ml	1.098 ml	2.195 ml
50 mM	0.044 ml	0.22 ml	0.439 ml