货号	规格	价格	上海	北京	珠海	重庆	武汉
S83889-1mg	≥98%	￥1230.00 S83889-1mg ￥1230.00 3-5天	0 货期：3-5天	-	-	-	-
S83889-5mg	≥98%	￥3710.00 S83889-5mg ￥3710.00 3-5天	0 货期：3-5天	-	-	-	-
S83889-10mg	≥98%	￥5930.00 S83889-10mg ￥5930.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.

靶点：

Tau Protein;Others

体外研究：

Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). 18F-THK5351 binds to Alzheimer disease hippocampal homogenates with high affinity (Kd=2.9 nM; maximum number of binding sites=368.3 pmol/g tissue). It has fast dissociation from white-matter tissue. The THK5351 binding amount correlates with the amount of tau deposits in tissue

体内研究：

THK5351 exhibits favorable pharmacokinetics and no defluorination in mice. 18F-THK5351 enters the brain immediately after intravenous injection and shows a fast washout from the brain. At 0.1 and 1 mg/kg, no animals died and no treatment-related changes in any animal are noted in clinical observations, body weight measurement, and pathologic examination. Autoradiography in the brain sections of patients with PSP demonstrates [3H]THK-5351 binding to tau deposits with a high selectivity. Although patients with PSP exhibits no remarkable [18F]THK-5351 retention in the temporal cortex, significantly higher tracer retention is observed in the globus pallidus and midbrain

参考文献：

1. Harada R, et al. 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease. J Nucl Med. 2016 Feb;57(2):208-14. 2. Ishiki A, et al. Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy. Eur J Neurol. 2017 Jan;24(1):130-136.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.055 ml	15.274 ml	30.548 ml
5 mM	0.611 ml	3.055 ml	6.11 ml
10 mM	0.305 ml	1.527 ml	3.055 ml
50 mM	0.061 ml	0.305 ml	0.611 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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