货号	规格	价格	上海	北京	珠海	重庆	武汉
S83927-1mg	≥97%	￥445.00 S83927-1mg ￥445.00 3-5天	0 货期：3-5天	-	-	-	-
S83927-2mg	≥97%	￥800.00 S83927-2mg ￥800.00 3-5天	0 货期：3-5天	-	-	-	-
S83927-5mg	≥97%	￥1330.00 S83927-5mg ￥1330.00 3-5天	0 货期：3-5天	-	-	-	-
S83927-10mg	≥97%	￥2000.00 S83927-10mg ￥2000.00 3-5天	0 货期：3-5天	-	-	-	-
S83927-25mg	≥97%	￥3400.00 S83927-25mg ￥3400.00 3-5天	0 货期：3-5天	-	-	-	-
S83927-50mg	≥97%	￥5700.00 S83927-50mg ￥5700.00 3-5天	0 货期：3-5天	-	-	-	-
S83927-100mg	≥97%	￥7800.00 S83927-100mg ￥7800.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively

靶点：

IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells);Others

体外研究：

HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity

参考文献：

1. Tanaka H, et al. Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: drug-western. Mol Pharmacol. 1999 Feb;55(2):356-63.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.729 ml	13.645 ml	27.29 ml
5 mM	0.546 ml	2.729 ml	5.458 ml
10 mM	0.273 ml	1.365 ml	2.729 ml
50 mM	0.055 ml	0.273 ml	0.546 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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