源叶(MedMol)
S83956
一键复制产品信息
17528-72-2
C9H15N5O3
241.25
四氢生物喋呤;5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinon;5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinone;bh4;TETRAHYDRO-L-BIOPTERIN, DIHYDROCHLORIDE;THB, 2HCL;6R
Tetrahydrobiopterin 99.86%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83956-5mg |
99.86% | ￥840.00 |
2 | 1 | - | - | - |
|
S83956-10mg |
99.86% | ￥1350.00 |
1 | - | - | - | - |
|
S83956-50mg |
99.86% | ￥6700.00 |
4 | - | - | - | - |
|
| 产品描述： | Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms. |
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| 靶点： | Human Endogenous Metabolite;NOS; EndogenousMetabolite | ||||||||||||||||||||
| 体内研究： | To assess the levels of Tetrahydrobiopterin in the retina, three to five pools of retinas are collected from WT and hph-1mice at postnatal age 7, 14, and 22 and evaluated by LC-MS/MS. LC-MS/MS analysis confirm a significant decrease by approximately 90% in the concentration levels of Tetrahydrobiopterin in retinal tissue from hph-1 mice (0.0009±0.0006; p<0.0001, 0.01±0.001; p<0.0001 and 2.45±0.40; p<0.005) compare to the WT group (0.014±0.001, 0.092±0.01, and 23.13±6.44) at P7, P14, and P22, respectively | ||||||||||||||||||||
| 参考文献： | 1. Rivera JC, et al. Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina. J Neuroinflammation. 2017 Sep 6;14(1):181. | ||||||||||||||||||||
| 溶解性： | DMSO : 50 mg/mL (207.25 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献(5篇)
5. [IF=6.2] Jin Han et al."Structure-Guided Engineering of Tryptophan Hydroxylase Relieves Tunnel Congestion and Substrate Trapping to Enhance 5-Hydroxytryptophan Biosynthesis."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
4. [IF=13.1] Li Hongcheng et al."Ligand specificity and adaptability revealed by the first Guanine-II riboswitch tertiary structure."NUCLEIC ACIDS RESEARCH.2025 Sep;53(17):
3. [IF=14.9] Li Chunyan et al."Structure-based characterization and compound identification of the wild-type THF class-II riboswitch."NUCLEIC ACIDS RESEARCH".2024 May;:
2. [IF=5] Xiaoling Jiang et al."Mechanisms underlying the efficacy and limitation of dopa and tetrahydrobiopterin therapies for the deficiency of GTP cyclohydrolase 1 revealed in a novel mouse model."EUROPEAN JOURNAL OF PHARMACOLOGY".2024 Feb;:176379
1. [IF=5.81] Yan Tao et al."Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH4/eNOS to Improve Intestinal Ischemia."Front Pharmacol. 2021 Apr;0:893
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