货号	规格	价格	上海	北京	珠海	重庆	武汉
S83986-5mg	≥98%	￥920.00 S83986-5mg ￥920.00 3-5天	0 货期：3-5天	-	-	-	-
S83986-10mg	≥98%	￥1220.00 S83986-10mg ￥1220.00 3-5天	0 货期：3-5天	-	-	-	-
S83986-50mg	≥98%	￥3660.00 S83986-50mg ￥3660.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Pyridostatin (RR82) hydrochloride is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin hydrochloride promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin hydrochloride targets the proto-oncogene Src. Pyridostatin hydrochloride reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells

靶点：

Kd: 490 nM (G-quadruplexe)

体外研究：

Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest. Pyridostatin hydrochloride is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin hydrochloride causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin hydrochloride induces the formation of DNA DSBs. Remarkably, Pyridostatin hydrochloride (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level Cell Viability Assay Cell Line: Over 60 different cancer cell lines Concentration: 10 μM Incubation Time: 48 hours Result: Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines.

参考文献：

1. Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8(3):301-310. Published 2012 Feb 5. 2. Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3(10):782-787. Published 2011 Aug 28. 3. Moruno-Manchon JF, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017;9(9):1957-1970.

溶解性：

Soluble in H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.284 ml	6.419 ml	12.838 ml
5 mM	0.257 ml	1.284 ml	2.568 ml
10 mM	0.128 ml	0.642 ml	1.284 ml
50 mM	0.026 ml	0.128 ml	0.257 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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Pyridostatin (hydrochloride)