货号	规格	价格	上海	北京	珠海	重庆	武汉
S83990-1mg	≥98%	￥100.00 S83990-1mg ￥100.00 现货	5 5	-	-	-	-
S83990-2mg	≥98%	￥199.00 S83990-2mg ￥199.00 现货	5 5	-	-	-	-
S83990-5mg	≥98%	￥270.00 S83990-5mg ￥270.00 现货	7 7	-	-	-	-
S83990-10mg	≥98%	￥380.00 S83990-10mg ￥380.00 现货	4 4	-	-	-	-
S83990-25mg	≥98%	￥650.00 S83990-25mg ￥650.00 现货	4 4	-	-	-	-
S83990-50mg	≥98%	￥950.00 S83990-50mg ￥950.00 2-3天	0 货期：2-3天	-	-	-	-
S83990-100mg	≥98%	￥1610.00 S83990-100mg ￥1610.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295

靶点：

p38 MAPK;Autophagy;p38MAPK; Autophagy

体外研究：

TA-02 (5 μM) inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis. TA-02 at 5 μM concentration induces cardiogenesis, but also increases ATF-2 phosphorylation and MEF2C õexpression in contrast to what would be expected with a mechanism dependent on p38α MAPK inhibition. TA-02 induces T/Brachyury whereas SB203580 addition increased MESP1 and T/Brachyury transcripts. TA-02 significantly induces high NKX2-5 expression when applied between days 0-8. TA-02 is found to inhibit multiple targets with similar potency to p38α MAPK, such as p38α, p38β, JNK3, JNK2, CIT, CK1ε, DMPK2, JNK1, DDR1 CK1δ, MEK5, and ERBB2. TA-02 and SB203580 reduce the nuclear TCF/LEF-1 driven transcription of luciferase similar to DKK-1.TA-02 (5 nM-5 μM) inhibits p38 and increases the anti-inflammation effects of BDNF on inflammation in vitro. Western Blot Analysis Cell Line: The nerve cell line AGE1.HN. Concentration: 5 nM-5 μM. Incubation Time: 44 h (100 ng/ml LPS for 4 h at 37°C). Result: Suppressed p-38 protein expression, reduced IL-1β, IL-6, IL-18 and TNF-α levels and inhibited iNOS and COX-2 levels in an in vitro model of SCI by BDNF overexpression, compared with the BDNF overexpression group.

参考文献：

1. Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70. 2. Jiedong Liang, et al. The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling. Exp Ther Med. 2019 Mar;17(3):1688-1696.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3 ml	15 ml	30 ml
5 mM	0.6 ml	3 ml	6 ml
10 mM	0.3 ml	1.5 ml	3 ml
50 mM	0.06 ml	0.3 ml	0.6 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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