货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S83998-10mg	≥96%	￥1370.00 S83998-10mg ￥1370.00 3-5天	0 货期：3-5天	-	-	-	-
S83998-50mg	≥96%	￥3430.00 S83998-50mg ￥3430.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7

靶点：

pKi: 7.7 (NMDA receptor);Others

体内研究：

SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action. Animal Model: Male OF-l mice (18-26 g) Dosage: 3.2 mg/kg, 10 mg/kg, 32 mg/kg Administration: Oral administration; for 24 hours Result: Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration.

参考文献：

1. Urwyler S, et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology. 1996 Jun;35(6):655-69. 2. Gilmour G, et al. In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.462 ml	12.309 ml	24.619 ml
5 mM	0.492 ml	2.462 ml	4.924 ml
10 mM	0.246 ml	1.231 ml	2.462 ml
50 mM	0.049 ml	0.246 ml	0.492 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

SDZ 220-581 (hydrochloride)