货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S84012-5mg	≥98%	￥1190.00 S84012-5mg ￥1190.00 3-5天	0 货期：3-5天	-	-	-	-
S84012-10mg	≥98%	￥1980.00 S84012-10mg ￥1980.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM

靶点：

PLK4:0.59 nM (Ki);PLK4 (G95L):497.53 nM (Ki);Aurora A:1239 nM (Ki);Aurora B:5597.14 nM (Ki);AuroraKinase

体外研究：

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Centrinone-B slightly binds to Aurora A and Aurora B, with Kis of 1239 nM and 5597.14 nM. Centrinone-B (LCR-323) exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes. Centrinone-B (LCR-323) (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Inhibition of PLK4 by Centrinone-B (LCR-323) also induces apoptosis in human melanoma cell lines

参考文献：

1. Wong YL, et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348(6239):1155-60. 2. Denu RA, et al. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. 2018 Jan 12.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.583 ml	7.915 ml	15.831 ml
5 mM	0.317 ml	1.583 ml	3.166 ml
10 mM	0.158 ml	0.792 ml	1.583 ml
50 mM	0.032 ml	0.158 ml	0.317 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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