货号	规格	价格	上海	北京	珠海	重庆	武汉
S84112-5mg买3赠1	98.00%	￥240.00 S84112-5mg ￥240.00 现货（买3赠1）	7 7	-	-	-	-
S84112-10mg买3赠1	98.00%	￥416.00 S84112-10mg ￥416.00 现货（买3赠1）	8 8	-	-	-	-
S84112-25mg买3赠1	98.00%	￥840.00 S84112-25mg ￥840.00 现货（买3赠1）	9 9	-	-	-	-
S84112-50mg促销	98.00%	￥1480.00 ￥1180.00 S84112-50mg ￥1180.00 现货	11 >10	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

NS309 is a potent and selective activator of the Ca2+-activated SK/IK potassium channels, but displays no activity at BK channels

靶点：

EC50: 0.62 µM (SK2), 0.3 μM (SK3), ∼20 nM (KCa3.1/SK4), ∼600 nM (KCa2/SK channels)[3], 10 nM (hIK);EGFR; PotassiumChannel; HER

体内研究：

NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits

参考文献：

1. Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons. 2. C Hougaard, et al. Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul; 151(5): 655–665. 3. Nichole Coleman, et al. New Positive Ca2+-Activated K+ Channel Gating Modulators with Selectivity for KCa3.1. Mol Pharmacol. 2014 Sep; 86(3): 342–357. 4. Dorte Strøbaek, et al. Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim Biophys Acta. 2004 Oct 11;1665(1-2):1-5. 5. Shankar P Parajuli, et al. NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels. Br J Pharmacol. 2013 Apr; 168(7): 1611–1625. 6. Jie Zhu, et al. Activation of SK/KCa Channel Attenuates Spinal Cord Ischemia-Reperfusion Injury via Anti-oxidative Activity and Inhibition of Mitochondrial Dysfunction in Rabbits. Front Pharmacol. 2019; 10: 325.

溶解性：

DMSO : 100 mg/mL (432.83 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.328 ml	21.641 ml	43.283 ml
5 mM	0.866 ml	4.328 ml	8.657 ml
10 mM	0.433 ml	2.164 ml	4.328 ml
50 mM	0.087 ml	0.433 ml	0.866 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置