货号	规格	价格	上海	北京	珠海	重庆	武汉
S84140-5mg促销	≥99%(HPLC)	￥640.00 ￥510.00 S84140-5mg ￥510.00 现货	10 10	-	-	-	-
S84140-10mg促销	≥99%(HPLC)	￥900.00 ￥710.00 S84140-10mg ￥710.00 现货	6 6	-	-	-	-
S84140-25mg促销	≥99%(HPLC)	￥1700.00 ￥1350.00 S84140-25mg ￥1350.00 现货	3 3	-	-	-	-
S84140-50mg促销	≥99%(HPLC)	￥2900.00 ￥2310.00 S84140-50mg ￥2310.00 现货	1 1	-	-	-	-

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产品描述：

Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.

靶点：

Ki: 5.2 nM (dopamine D4 receptor);DopamineReceptor

体外研究：

RO-10-5824 shows high affinity binding with a Ki=5.2±0.9 nM (n=3), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates 35S-GTPγS binding with an EC50 value of 205±67 nM (n=7) and maximal induction at 36±4% above basal level

体内研究：

Ro 10-5824 (3 mg/kg) increases the success rate in the ORD task. At doses of 1 and 3 mg/kg, Ro 10-5824 increases baseline gamma band activity in the frontal cortex. Ro 10-5824 has no effect on spontaneous locomotion. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice

参考文献：

1. Nakazawa S, et al. Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets. Psychopharmacology (Berl). 2015 Sep;232(17):3287-95. 2. Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44(4):473-81.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃;干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.831 ml	14.153 ml	28.305 ml
5 mM	0.566 ml	2.831 ml	5.661 ml
10 mM	0.283 ml	1.415 ml	2.831 ml
50 mM	0.057 ml	0.283 ml	0.566 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Ro 10-5824 二盐酸盐

Ro 10-5824 (dihydrochloride)

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)