C75

≥98%

C75

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品牌：源叶(MedMol)

产品编号：S84163 一键复制产品信息

CAS号：191282-48-1

分子式：C₁₄H₂₂O₄

分子量：254.32

别名：反-4-羧基-5-辛基-3-甲基-丁内酯;TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID;C75;4-METHYLENE-2-OCTYL-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID;trans-C 75 (trans-4-Methylene-2-octyl-5-oxo-tetrahydro-f

货号	规格	价格	上海	北京	珠海	重庆	武汉
S84163-1mg	≥98%	￥290.00 S84163-1mg ￥290.00 2-3天	0 货期：2-3天	-	-	-	-
S84163-5mg	≥98%	￥500.00 S84163-5mg ￥500.00 现货	8 8	-	-	-	-
S84163-25mg	≥98%	￥1270.00 S84163-25mg ￥1270.00 现货	1 1	-	-	-	-
S84163-100mg	≥98%	￥3250.00 S84163-100mg ￥3250.00 现货	2 2	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

C75 trans (trans-C75, (±)-C75) 是一种 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制剂，在成株试验和球体生长测定中的IC50值分别为35 μM和50 μM。C75 可用作研究代谢紊乱和癌症中脂肪酸合成的工具

靶点：

FASN(clonogenic assay):35 μM;FASN(spheroid growth assay):50 μM;FattyAcidSynthase

体内研究：

C75 inhibits fatty acid synthesis and in vivo mammary cancer development. C75 treatment prevents mammary cancer development and retards mammary development in neu-N transgenic mice.

细胞实验：

Cell lines: PC3 cells, LNCaP cells Concentrations: 5 μM, 25 μM, 35 μM, 50 μM Incubation Time: 3 h, 6 h, 24 h Method: PC3 cells are seeded in 25 cm2 flasks at 105 cells/flask. When cultures are in exponential growth phase, media is removed and replaced with fresh drug-containing media. Cells are then incubated for 24 h at 37℃ in 5% CO2. To determine optimal sequencing of therapeutic agents, three different combination treatment schedules are assessed: 1. radiation and C75 administered simultaneously; 2. radiation administered 24 h before C75; and 3. radiation administered 24 h after C75. After treatment, cells are seeded for clonogenic survival assay.

动物实验：

Animal Models: neu-N transgenic mice, FVB/N mice Dosages: 30mg/kg Administration: IP

参考文献：

1. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
2. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.
3. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.
4. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃;干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.932 ml	19.66 ml	39.321 ml
5 mM	0.786 ml	3.932 ml	7.864 ml
10 mM	0.393 ml	1.966 ml	3.932 ml
50 mM	0.079 ml	0.393 ml	0.786 ml