货号	规格	价格	上海	北京	珠海	重庆	武汉
S84178-5mg买3赠1	98.21%	￥830.00 S84178-5mg ￥830.00 现货（买3赠1）	6 6	-	-	-	-
S84178-10mg买3赠1	98.21%	￥1540.00 S84178-10mg ￥1540.00 现货（买3赠1）	7 7	-	-	-	-
S84178-25mg买3赠1	98.21%	￥3600.00 ￥3240.00 S84178-25mg ￥3240.00 现货（买3赠1）	6 6	-	-	-	-

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产品描述：

CTS-1027 is a potent small molecule inhibitor of MMPs, with IC50s of 0.3 nM, 0.5 nM for MMP2, MMP13, respectively, and has > 1,000 fold selectivity over MMP1.

靶点：

IC50: 0.2 nM (MMP2), 0.5 nM (MMP13), 0.7 nM (MMP12), 0.9 nM (MMP8), 9.5 nM (MMP3), 15 nM (MMP14);Others

体内研究：

CTS-1027 significantly reduces the hepatocyte apoptosis, features of cholestatic liver injury, amd markers of hepatic fibrogenesis in the BDL mouse. CTS-1027 improves overall animal survival following 14 days of BDL in mice. In male animals treated for 8 weeks the terminal plasma concentration of RS-130830 is 311±45 nM. Treatment of male mice with RS-130830 for 8 weeks causes an 89% increase in plasma triglyceride concentration, but there is no corresponding effect in female mice treated for 12 weeks. The plaque lipid content of animals receiving RS-130830 is increased by 81% at 12 weeks, and increased by 41% at 16 weeks

参考文献：

1. Kahraman A, et al. Matrix metalloproteinase inhibitor, CTS-1027, attenuates liver injury and fibrosis in the bile duct-ligated mouse. Hepatol Res. 2009 Aug;39(8):805-813. 2. Johnson JL, et al. Effect of broad-spectrum matrix metalloproteinase inhibition on atherosclerotic plaque stability. Cardiovasc Res. 2006 Aug 1;71(3):586-595.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.348 ml	11.74 ml	23.481 ml
5 mM	0.47 ml	2.348 ml	4.696 ml
10 mM	0.235 ml	1.174 ml	2.348 ml
50 mM	0.047 ml	0.235 ml	0.47 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=3.368] Xiaoying Kong et al."Application of a novel thermo-sensitive injectable hydrogel in therapy in situ for drug accurate controlled release."J Biomed Mater Res B. 2020 Nov;108(8):3200-3216

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