| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S84181-5mg促销 |
95.10% | ￥310.00 ￥248.00 |
8 | - | - | - | - |
|
S84181-10mg促销 |
95% | ￥550.00 ￥440.00 |
货期：2-3天 | - | - | - | - |
|
S84181-25mg |
95.10% | ￥1190.00 |
1 | - | - | - | - |
|
S84181-50mg |
95% | ￥2200.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a | ||||||||||||||||||||
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| 靶点： | Ki: 7 nM (hGHS-R1a);GHSR | ||||||||||||||||||||
| 体外研究： | Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM | ||||||||||||||||||||
| 体内研究： | Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv | ||||||||||||||||||||
| 参考文献： | 1. Zollers B, et al. Capromorelin oral solution (ENTYCE?) increases food consumption and body weight when administered for 4 consecutive days to healthy adult Beagle dogs in a randomized, masked, placebo controlled study. BMC Vet Res. 2017 Jan 5;13(1):10. 2. Carpino PA, et al. Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin. Bioorg Med Chem. 2003 Feb 20;11(4):581-90. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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