货号	规格	价格	上海	北京	珠海	重庆	武汉
S84189-5mg	≥99%	￥1080.00 S84189-5mg ￥1080.00 3-5天	0 货期：3-5天	-	-	-	-
S84189-10mg	≥99%	￥1860.00 S84189-10mg ￥1860.00 3-5天	0 货期：3-5天	-	-	-	-
S84189-25mg	≥99%	￥3280.00 S84189-25mg ￥3280.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

靶点：

5-HT3 Receptor;5-HTReceptor

体内研究：

Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors. Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit

参考文献：

1. Chetty N, et al. Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract. Pharmacology. 2008;81(2):104-9. Epub 2007 Oct 19. 2. Coleman NS, et al. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.943 ml	14.713 ml	29.426 ml
5 mM	0.589 ml	2.943 ml	5.885 ml
10 mM	0.294 ml	1.471 ml	2.943 ml
50 mM	0.059 ml	0.294 ml	0.589 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

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Pumosetrag Hydrochloride (MKC-733; DDP-733)

N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)