货号	规格	价格	上海	北京	珠海	重庆	武汉
S84215-10mg买3赠1	99.30%	￥390.00 S84215-10mg ￥390.00 现货（买3赠1）	6 6	-	-	-	-
S84215-50mg买3赠1	99.30%	￥680.00 S84215-50mg ￥680.00 现货（买3赠1）	6 6	-	-	-	-
S84215-100mg促销	99.30%	￥1020.00 ￥816.00 S84215-100mg ￥816.00 现货	4 4	-	-	-	-

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产品描述：

RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome

靶点：

IC50: 13 nM (RIP1);RIPkinase

体外研究：

RIPA-56 shows efficient inhibition of RIP1 kinase activity, with an IC50 of 13 nM and no inhibition of RIP3 kinase activity at a 10 μM concentration. RIPA-56 also demonstrates potency in protection of murine L929 cells from TNFα/z-VAD-FMK (TZ)-induced necrosis (EC50=27 nM)

体内研究：

In the SIRS mice disease model, RIPA-56 efficiently reduces tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage. Compared to known RIP1 inhibitors, RIPA-56 is potent in both human and murine cells, is much more stable in vivo, and is efficacious in animal model studies. RIPA-56 has an impressive PK profile in mice with a 3.1 h half-life, 22% oral bioavailability (P.O.), and 100% bioavailability from intraperitoneal injection (I.P.)

参考文献：

1. Ren Y, et al. Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-InteractingProtein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome. J Med Chem. 2017 Feb 9;60(3):972-986.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.519 ml	22.594 ml	45.188 ml
5 mM	0.904 ml	4.519 ml	9.038 ml
10 mM	0.452 ml	2.259 ml	4.519 ml
50 mM	0.09 ml	0.452 ml	0.904 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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