货号	规格	价格	上海	北京	珠海	重庆	武汉
S84255-1mg	≥98%	￥260.00 S84255-1mg ￥260.00 3-5天	0 货期：3-5天	-	-	-	-
S84255-5mg	≥98%	￥790.00 S84255-5mg ￥790.00 3-5天	0 货期：3-5天	-	-	-	-
S84255-10mg	≥98%	￥1280.00 S84255-10mg ￥1280.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

OABK hydrochloride is a small-molecule switch that can be used to control protein activity.

靶点：

Others

体外研究：

A small-molecule switch for the activation of protein function through the site-specific incorporation of an ortho-azidobenzyloxycarbonyl lysine (OABK). The amino acid OABK is synthesized readily in three steps from 2-azidobenzyl alcohol via a succinimidyl carbonate. Deprotection results in the formation of lysine and, when OABK is incorporated into a protein, the formation of active wild-type protein. Genetically encoded OABK in conjunction with small-molecule activation allows for the conditional regulation of intracellular protein maturation. Incorporation of OABK (0.5 mM) at position K85 of EGFP inhibits fluorophore formation until the native lysine is generated through small-molecule activation (the model is based on Protein Data Bank (PDB). Introducing OABK at position K206 inhibits FLuc enzymatic activity by restricting the access of adenosine triphosphate (ATP) to the active site, until the enzyme is deprotected and activated through phosphine treatment. The incorporation of OABK into FLuc blocks the luciferase activity in the absence of small-molecule activation, as determined by a Bright-Glo luciferase assay

参考文献：

1. Luo J, et al. Small-molecule control of protein function through Staudinger reduction. Nat Chem. 2016 Nov;8(11):1027-1034.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.795 ml	13.975 ml	27.949 ml
5 mM	0.559 ml	2.795 ml	5.59 ml
10 mM	0.279 ml	1.397 ml	2.795 ml
50 mM	0.056 ml	0.279 ml	0.559 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

OABK (hydrochloride)