| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S84283-1mg |
≥98% | ￥720.00 |
货期：3-5天 | - | - | - | - |
|
S84283-5mg |
≥98% | ￥1810.00 |
货期：3-5天 | - | - | - | - |
|
S84283-10mg |
≥98% | ￥2540.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | NAMI-A is a ruthenium-based drug characterized by the selective activity against tumor metastases. NAMI-A inhibits adhesion and migration. | ||||||||||||||||||||
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| 靶点： | CETP;FAK; CETP | ||||||||||||||||||||
| 体外研究： | NAMI-A can significantly affect tumor cells with metastatic ability. The half lifetime of NAMI-A elimination from the lungs is longer than for liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations. The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397 | ||||||||||||||||||||
| 参考文献： | 1. Pelillo C et al. Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem. 2016 Jul;160:225-35. 2. Sava G et al. Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen. Clin Cancer Res. 2003 May;9(5):1898-905. | ||||||||||||||||||||
| 溶解性： | Soluble in H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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