货号	规格	价格	上海	北京	珠海	重庆	武汉
S84344-5mg买3赠1	99.20%	￥300.00 S84344-5mg ￥300.00 现货（买3赠1）	4 4	-	-	-	-
S84344-10mg买3赠1	99.20%	￥480.00 S84344-10mg ￥480.00 现货（买3赠1）	5 5	-	-	-	-
S84344-25mg	99.20%	￥640.00 S84344-25mg ￥640.00 现货	6 6	-	-	-	-
S84344-50mg	≥98%	￥1200.00 S84344-50mg ￥1200.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).

靶点：

Sigma receptor;Sigmareceptor

体内研究：

BD 1063 dose-dependently reduced ethanol self-administration in sP rats (3.3–11 mg/kg) and withdrawn, dependent Wistar rats (4–11 mg/kg) at doses that did not modify mean ethanol self-administration in non-dependent Wistar controls

动物实验：

Rats (controls, N=11;?dependent, N=9) were pretreated with BD-1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights) using a within-subject Latin square design.?sP rats: Rats (N=9) were pretreated with BD-1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis) using a within-subject Latin square design

参考文献：

1.Nieto F R , Cruz Miguel Cendán, Cristina Sánchez-Fernández, et al. Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice[J]. The journal of pain: official journal of the American Pain Society, 2012, 13(11):1107-1121. 2.Sabino V , Cottone P , Zhao Y , et al. The σ-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking[J]. Neuropsychopharmacology, 2009, 34(6):1482-1493.

溶解性：

H2O:50 mg/mL (144.46 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.889 ml	14.446 ml	28.892 ml
5 mM	0.578 ml	2.889 ml	5.778 ml
10 mM	0.289 ml	1.445 ml	2.889 ml
50 mM	0.058 ml	0.289 ml	0.578 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

BD 1063 Dihydrochloride