| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S84347-5mg促销 |
≥96% | ￥408.00 ￥366.00 |
8 | - | - | - | - |
|
S84347-10mg促销 |
≥96% | ￥696.00 ￥626.00 |
货期：3-5天 | - | - | - | - |
|
S84347-25mg促销 |
≥96% | ￥1150.00 ￥1040.00 |
6 | - | - | - | - |
|
S84347-50mg促销 |
≥96% | ￥2230.00 ￥2010.00 |
7 | - | - | - | - |
|
S84347-100mg促销 |
≥96% | ￥3790.00 ￥3410.00 |
2 | - | - | - | - |
|
S84347-250mg促销 |
≥96% | ￥4910.00 ￥4420.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1β, IL-6 and IFN-β) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders, including epilepsy and parkinson's disease, et al | ||||||||||||||||||||
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| 靶点： | CREBBP:125 nM (IC50);EP300:363 nM (IC50);CBP:.19 μM (Kd);BRD4:20 μM (Kd);EpigeneticReaderDomain; HistoneAcetyltransferase | ||||||||||||||||||||
| 体外研究： | ITC is the label-free technique for determining KD values, PF-CBP1 is against CBP (Kd=0.19 μM) and >105-fold selective over BRD4 (Kd>20 μM) by ITC. PF-CBP1 displays greater than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins, it against BRD2-1,BRD3-1, BRD3-2,BRD4-1, BRD4-2, BRDT-1, TAF1-2, and TAF1L-2 with IC50 values of 1.24 μM, 1.38 μM, 4.22 μM, 1.54 μM, 9.75 μM, 2.44 μM, 3.39 μM and 7.29 μM, respectively. PF-CBP1 (3-10 μM; pretreatment 30 mins; 4 hours) moderately reduces LPS-induced IL-6 and IFN-b expression in the J774 cell at 10 μM. And it decreases IL-1b expression evidently at 3 μM. PF-CBP1 (100 nM-1000 nM;24 hours) significantly reduced RGS4 mRNA levels(49% reduction) relative to vehicle in cortical neuron cells | ||||||||||||||||||||
| 参考文献： | 1. Chekler EL, et al. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec 17;22(12):1588-96. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京