| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S84399-2mg买3赠1 |
98.10% | ￥200.00 |
5 | - | - | - | - |
|
S84399-10mg促销 |
98.10% | ￥370.00 ￥296.00 |
5 | - | - | - | - |
|
S84399-5mg买3赠1 |
98.10% | ￥300.00 |
5 | - | - | - | - |
|
S84399-25mg促销 |
98.10% | ￥590.00 ￥472.00 |
4 | - | - | - | - |
|
S84399-50mg促销 |
≥98% | ￥1020.00 ￥816.00 |
货期：2-3天 | - | - | - | - |
|
S84399-100mg促销 |
≥98% | ￥1870.00 ￥1490.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Farampator (CX-691;Org24448) is a positive modulator of AMPA receptor. | ||||||||||||||||||||
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| 靶点： | GluR;iGluR;GluR; iGluR | ||||||||||||||||||||
| 体内研究： | Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia. CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.)[1]. Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Besides, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs | ||||||||||||||||||||
| 参考文献： | 1.Woolley ML, et al. Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54. 2.Wezenberg E, et al. Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers. Neuropsychopharmacology. 2007 Jun;32(6):1272-83. | ||||||||||||||||||||
| 溶解性： | DMSO:34 mg/mL | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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