货号	规格	价格	上海	北京	珠海	重庆	武汉
S84449-1mg	≥98%	￥1400.00 S84449-1mg ￥1400.00 3-5天	0 货期：3-5天	-	-	-	-
S84449-5mg	≥98%	￥4200.00 S84449-5mg ￥4200.00 3-5天	0 货期：3-5天	-	-	-	-
S84449-10mg	≥98%	￥6200.00 S84449-10mg ￥6200.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4. In vitro: SCH00013 at 10-4 M increased the systolic cell shortening by 52% above the base-line value in association with an insignificant increase in the systolic fluorescence ratio by 15% above the control. In vivo: The positive inotropic effects of 10 4 M SCH00013 on the dog and rabbit were 38% and 29% of the maximal response to isoproterenol. CH00013 elicited a positive inotropic effect at more than 0.3 and 1 mg/kg, i.v. in normal and heart failure dogs.SCH00013 elicits a positive inotropic effect mainly through an increase in myofilament Ca2+ sensitivity without increasing the heart rate

靶点：

Others

参考文献：

1. Sugawara H et al. A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22. 2. Tadano N et al. SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure. J Pharmacol Sci. 2005 Jan;97(1):53-60. 3. Endoh M et al. Pharmacology of SCH00013: a novel Ca2+ sensitizer. Cardiovasc Drug Rev. 2001 Winter;19(4):345-66.

溶解性：

DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.083 ml	15.414 ml	30.828 ml
5 mM	0.617 ml	3.083 ml	6.166 ml
10 mM	0.308 ml	1.541 ml	3.083 ml
50 mM	0.062 ml	0.308 ml	0.617 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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