货号	规格	价格	上海	北京	珠海	重庆	武汉
S84476-1mg	≥98%	￥1490.00 S84476-1mg ￥1490.00 3-5天	0 货期：3-5天	-	-	-	-
S84476-5mg	≥98%	￥3490.00 S84476-5mg ￥3490.00 3-5天	0 货期：3-5天	-	-	-	-
S84476-10mg	≥98%	￥4990.00 S84476-10mg ￥4990.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

UKI-1 (UKI-1C) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 0.41 μM. UKI-1 is also a low molecular weight serine protease inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells

靶点：

Ki: 0.41 μM (Urokinase-type plasminogen activator (uPA)) Serine protease;Others

体外研究：

UKI-1 (WX-UK1; 0.1-1.0 μg/mL) treatment shows a decrease of tumor cell invasion by up to 50% is achieved in both models with the SCCHN line FaDu and the cervical carcinoma line HeLa. UKI-1 (WX-UK1) interferes with the plasminogen activation system at 2 levels: it inhibits plasmin formation directly and via inhibition of uPA. In vitro invasion models with highly invasive fibrosarcoma and breast cancer cells showed that UKI-1 effectively inhibits migration of the cells through fibrin matrices

体内研究：

UKI-1 (WX-UK1) treatment has antimetastatic activities that significantly reduces the number of metastatic lesions and tumor growth in metastasizing rat pancreatic and mammary adenocarcinoma tumor models

参考文献：

1. Ertongur S et al. Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system. Int J Cancer. 2004 Jul 20;110(6):815-24. 2. Ewa Zeslawska et al. Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design. J Mol Biol. 2000 Aug 11;301(2):465-75.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.629 ml	8.146 ml	16.292 ml
5 mM	0.326 ml	1.629 ml	3.258 ml
10 mM	0.163 ml	0.815 ml	1.629 ml
50 mM	0.033 ml	0.163 ml	0.326 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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