Bromocriptine mesylate

≥99%

Bromocriptine mesylate

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品牌：源叶(MedMol)

产品编号：S84497 一键复制产品信息

CAS号：22260-51-1

分子式：C₃₃H₄₄BrN₅O₈S

分子量：750.7

别名：甲磺酸溴隐亭;2-溴-alpha-麦角环肽甲磺酸盐;甲黄酸溴麦角环肽;2-溴-Α-麦角隐亭甲磺酸盐;(5'A)-2-BROMO-12'-HYDROXY-2'-(1-METHYLETHYL)-5'-(2-METHYLPROPYL)ERGOTAMAN-3',6',18-TRIONE MESYLATE;(+)-2-BROMO-12'-HYDROXY-2'-(1-METHYLETHYL)-5'-(2-ME

货号	规格	价格	上海	北京	珠海	重庆	武汉
S84497-50mg	≥99%	￥340.00 S84497-50mg ￥340.00 2-3天	0 货期：2-3天	-	-	-	-
S84497-100mg	99.80%	￥420.00 S84497-100mg ￥420.00 现货	2 2	-	-	-	-
S84497-500mg	≥99%	￥1680.00 S84497-500mg ￥1680.00 2-3天	0 货期：2-3天	-	-	-	-

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产品介绍参考文献(3篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

靶点：

pKi: 8.05±0.2 (dopamine D2 receptor);DopamineReceptor; Autophagy

体内研究：

Bromocriptine mesylate (2 mg/kg, i.p.) is administered for 7 days in groups of mice in forced swimming test (FST) and tail suspension test (TST). Bromocriptine group shows significant anti-immobility action as compared to control. When Bromocriptine administered 30 min after the last dose of 7 days MPE treatment and subjected to FST, this dopaminergic agonist produces significant and dose dependent potentiation of anti-immobility action of MPE (200 mg/kg, p.o.) as compared to MPE treatment alone. Bromocriptine treatment group shows a significant reduction of immobility time as compared to control. Bromocriptine administration after 7 days pretreatment with MPE (100 and 200 mg/kg, p.o.) shows significant and dose dependent potentiation of anti-immobility action of MPE as compared to MPE treatment alone. Intracisternal administration of Bromocriptine decreases significantly the static mechanical allodynia (SMA) score compared to that of sham (saline-injected rats) and its effect lasted for 30 min. Intraperitoneal administration of Bromocriptine induces a significant, dose dependent (0.1 mg and 1 mg/kg) decrease in pain scores in CCI-IoN group when compared to sham and its effect lasted for 6 h. The highest dose induces the highest score decrease (P<0.01). Bromocriptine effect lasts for 20 min. Intraperitoneal administration of Bromocriptine induces a significant dose dependent decrease in SMA score in CCI-IoN+6-OHDA lesioned group compared to that of sham. Its effect lasts for 6 h

参考文献：

1. Gardner B, et al. Agonist action at D2(long) dopamine receptors: ligand binding and functional assays. Br J Pharmacol. 1998 Jul;124(5):978-84. 2. Renodon A, et al. Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects.FEBS Lett. 1997 Apr 7;406(1-2):33-6. 3. Wynalda MA, et al. Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen. Drug Metab Dispos. 1997 Oct;25(10):1211-4. 4. Rana DG, et al. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. 2014 Jan;35(1):90-7. 5. Dieb W, et al. Nigrostriatal dopaminergic depletion increases static orofacial allodynia. J Headache Pain. 2016;17:11.

溶解性：

DMSO : 50 mg/mL (66.60 mM; ultrasonic and warming and heat to 60°C) H2O : 1.1 mg/mL (1.47 mM; ultrasonic and adjust pH to 3 with HCl)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.332 ml	6.66 ml	13.321 ml
5 mM	0.266 ml	1.332 ml	2.664 ml
10 mM	0.133 ml	0.666 ml	1.332 ml
50 mM	0.027 ml	0.133 ml	0.266 ml