首页
订购/客服:400-666-5481

SJG-136

    
Moligand™, ≥98%

SJG-136

源叶(MedMol)
S84574 一键复制产品信息
232931-57-6
C31H32N4O6
556.609
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S84574-1mg促销
Moligand™, ≥98%

¥2800.00 ¥2240.00

10 - - - -
S84574-5mg促销
Moligand™, ≥98%

¥4900.00 ¥3920.00

7 - - - -
S84574-10mg促销
Moligand™, ≥98%

¥7400.00 ¥5920.00

4 - - - -
S84574-25mg促销
Moligand™, ≥98%

¥14800.00 ¥11840.00

2 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.
靶点: Pyrrolobenzodiazepines
体外研究: SJG-136 (dimer 5) is a DNA cross-linking agent, with an XL50 (concentration of agent required for 50% cross-linking of pBR322 DNA) of 45 nM for pBR322 DNA. SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC50, 22.5 pM), A2780cisR (IC50, 24 pM), CH1 (IC50, 0.12 nM), CH1cisR (IC50, 0.6 nM), and SKOV-3 (IC50, 9.1 nM). SJG-136 (SG2000) also reduces the viability of a panel of canine cancer cells, with GI50 values ranging from 0.33 - >100 nM after a 1 h exposure, and <0.03 - 17.33 nM following continuous exposure
体内研究: SJG-136 shows more potent antitumor effect against CMeC-1 tumour at 0.30 mg/kg than 0.15 mg/kg either as a single dose or administered once a week for three weeks via dosed intravenously in mice. SJG-136-induced H2AX phosphorylation shows good correspondence, but less sensitivity, than measurement of foci
参考文献: 1. Gregson SJ, et al. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem. 2001 Mar 1;44(5):737-48. 2. Mellinas-Gomez M, et al. Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours. BMC Vet Res. 2015 Aug 19;11:215.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.797 ml 8.983 ml 17.966 ml
5 mM 0.359 ml 1.797 ml 3.593 ml
10 mM 0.18 ml 0.898 ml 1.797 ml
50 mM 0.036 ml 0.18 ml 0.359 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

如何获取质检证书(COA)?
请输入货号和一个与之匹配的批号。
例如:
批号:JS298415 货号:S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

=
×
×