货号	规格	价格	上海	北京	珠海	重庆	武汉
S84574-1mg促销	Moligand™, ≥98%	￥2800.00 ￥2240.00 S84574-1mg ￥2240.00 现货	10 10	-	-	-	-
S84574-5mg促销	Moligand™, ≥98%	￥4900.00 ￥3920.00 S84574-5mg ￥3920.00 现货	7 7	-	-	-	-
S84574-10mg促销	Moligand™, ≥98%	￥7400.00 ￥5920.00 S84574-10mg ￥5920.00 现货	4 4	-	-	-	-
S84574-25mg促销	Moligand™, ≥98%	￥14800.00 ￥11840.00 S84574-25mg ￥11840.00 现货	2 2	-	-	-	-

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产品描述：

SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.

靶点：

Pyrrolobenzodiazepines

体外研究：

SJG-136 (dimer 5) is a DNA cross-linking agent, with an XL50 (concentration of agent required for 50% cross-linking of pBR322 DNA) of 45 nM for pBR322 DNA. SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC50, 22.5 pM), A2780cisR (IC50, 24 pM), CH1 (IC50, 0.12 nM), CH1cisR (IC50, 0.6 nM), and SKOV-3 (IC50, 9.1 nM). SJG-136 (SG2000) also reduces the viability of a panel of canine cancer cells, with GI50 values ranging from 0.33 - >100 nM after a 1 h exposure, and <0.03 - 17.33 nM following continuous exposure

体内研究：

SJG-136 shows more potent antitumor effect against CMeC-1 tumour at 0.30 mg/kg than 0.15 mg/kg either as a single dose or administered once a week for three weeks via dosed intravenously in mice. SJG-136-induced H2AX phosphorylation shows good correspondence, but less sensitivity, than measurement of foci

参考文献：

1. Gregson SJ, et al. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem. 2001 Mar 1;44(5):737-48. 2. Mellinas-Gomez M, et al. Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours. BMC Vet Res. 2015 Aug 19;11:215.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.797 ml	8.983 ml	17.966 ml
5 mM	0.359 ml	1.797 ml	3.593 ml
10 mM	0.18 ml	0.898 ml	1.797 ml
50 mM	0.036 ml	0.18 ml	0.359 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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