货号	规格	价格	上海	北京	珠海	重庆	武汉
S84615-5mg买3赠1	99.60%	￥780.00 S84615-5mg ￥780.00 现货（买3赠1）	5 5	-	-	-	-
S84615-10mg促销	99.60%	￥1260.00 ￥1000.00 S84615-10mg ￥1000.00 现货	7 7	-	-	-	-
S84615-25mg促销	99.60%	￥2250.00 ￥1800.00 S84615-25mg ￥1800.00 现货	5 5	-	-	-	-
S84615-100mg促销	≥98%	￥4910.00 ￥3920.00 S84615-100mg ￥3920.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model

靶点：

AGE

体外研究：

LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours. LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours. LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells. Cell Viability Assay Cell Line: THP-1 cells Concentration: 0, 25, 50, 100, and 200 μM Incubation Time: 24 hours Result: Showed no cytotoxicity to THP-1 cells. RT-PCR Cell Line: THP-1 cells Concentration: 0, 25, 50, 100, and 200 μM Incubation Time: One hour before S100b addition for 4 hours Result: Dose-dependently inhibited mRNA expression of RAGE, MCP-1, COX-2, IP-10, and NOX2 stimulated with S100b.

体内研究：

LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats. LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation. Animal Model: Male ZDF rats (13 to 40 weeks) Dosage: 50 mg/L Administration: P.O. for 27 weeks Result: Significantly reduced plasma triacylglycerol and cholesterol by ∼55% and ∼30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight.

参考文献：

1. Figarola JL, et al. Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes. Diabetes. 2007 Mar;56(3):647-55.
2. Figarola JL, et al. LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat. Diabetologia. 2008 May;51(5):882-91.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.409 ml	7.046 ml	14.093 ml
5 mM	0.282 ml	1.409 ml	2.819 ml
10 mM	0.141 ml	0.705 ml	1.409 ml
50 mM	0.028 ml	0.141 ml	0.282 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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