货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S84759-1mg	≥98%	￥1490.00 S84759-1mg ￥1490.00 3-5天	0 货期：3-5天	-	-	-	-
S84759-5mg	≥98%	￥4990.00 S84759-5mg ￥4990.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

DPC-681 is a potent and selective HIV protease inhibitor (IC90s: 4 to 40 nM for wild-type HIV-1).

体外研究：

DPC 681 displays no loss in potency toward recombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions. When all of the HIV-1 strains tested are considered, the average concentrations required for 90% inhibition of replication were 7.3 ± 3.4 for DPC 681.

体内研究：

The total body clearance (CL) of DPC 681 in dogs was high (1.8 liters/h/kg) equaling hepatic blood flow for this species (1.8 liters/h/kg). The Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively), after oral dosing. These data show that hepatic extraction (first-pass effect) can be saturated in the dog

参考文献：

1. Kaltenbach RF 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8.

溶解性：

10 mM in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.493 ml	7.464 ml	14.929 ml
5 mM	0.299 ml	1.493 ml	2.986 ml
10 mM	0.149 ml	0.746 ml	1.493 ml
50 mM	0.03 ml	0.149 ml	0.299 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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