货号	规格	价格	上海	北京	珠海	重庆	武汉
S84784-1mg	≥98%	￥990.00 S84784-1mg ￥990.00 3-5天	0 货期：3-5天	-	-	-	-
S84784-5mg	≥98%	￥2390.00 S84784-5mg ￥2390.00 3-5天	0 货期：3-5天	-	-	-	-
S84784-10mg	≥98%	￥3460.00 S84784-10mg ￥3460.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

TN1 is a potent fetal hemoglobin (HbF) inducer.

靶点：

fetal hemoglobin (HbF)

体外研究：

A high-throughput screen of a large chemical library identifies a 2,6-diamino-substituted purine, TN1, which induces fetal hemoglobin (HbF) more potently than hydroxyurea in KU812 and K562 leukemia cell lines.TN1 increases HbF protein in both leukemic KU812 and K562 cells in a dose-dependent manner. At 100 nM concentration, Western blot analysis indicated that TN1 increased γ-globin expression (2.9- and 3.7-fold increase in KU812 cell and K562 cell, respectively) to higher levels than 50-100 μM HU (1.8- and 1.9-fold increase in KU812 cell and K562 cell, respectively), the first drug approved for the treatment of SCD. The EC50 value for TN1-mediated HbF induction is approximately three orders of magnitude lower than that of HU (HU: EC50=50-100 μM; TN1: EC50=100 nM). In addition, TN1 is more potent than a number of previously reported small-molecule HbF inducers including sodium butyrate and other histone deacetylase (HDAC) inhibitors. At the concentrations tested, TN1, as well as hemin and HU, increase γ-globin mRNA transcription (greater than fourfold), indicating that TN1 increases γ-globin levels at both the transcriptional and protein level. The time course of TN1-induced γ-globin mRNA and protein synthesis is measured and both increase after approximately 24 h of treatment. TN1 also induces β-globin mRNA in addition to γ-globin mRNA, similar to hydroxyurea

参考文献：

1. Nam TG, et al. Identification and characterization of small-molecule inducers of fetal hemoglobin. ChemMedChem. 2011 May 2;6(5):777-80.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.962 ml	9.812 ml	19.623 ml
5 mM	0.392 ml	1.962 ml	3.925 ml
10 mM	0.196 ml	0.981 ml	1.962 ml
50 mM	0.039 ml	0.196 ml	0.392 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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