货号	规格	价格	上海	北京	珠海	重庆	武汉
S84801-5mg买3赠1	98.50%	￥990.00 S84801-5mg ￥990.00 现货（买3赠1）	5 5	-	-	-	-
S84801-10mg促销	98.50%	￥1690.00 ￥1350.00 S84801-10mg ￥1350.00 现货	5 5	-	-	-	-
S84801-25mg促销	98.50%	￥2990.00 ￥2390.00 S84801-25mg ￥2390.00 现货	5 5	-	-	-	-

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产品描述：

IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1). IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively

靶点：

Mcl-1;BCL;Antibacterial

体外研究：

IMB-XH1 (Compound 2) is a Mcl-1 inhibitor. IMB-XH is screened out with the IC50 value of 0.4637 μM at the concentration of 20 μg/mL. IMB-XH1 (20 μg/mL) can increase the sensitivity of E. coli BL21 (DE3) (pET-30a(+)-NDM-1) to ampicillinby more than 8 times. IMB-XHI may have a broad spectrum of metallo-β-lactamases (MBLs) inhibitory activity. The combination of IMB-XH1 and Meropenem (MEM) may have potentials to treat infections caused by metallo-β-lactamases-positive, carbapenem-resistant Gram-negative pathogens

参考文献：

1. Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9. 2. Jiangxue Han, et al. IMB-XH1 identified as a novel inhibitor of New Delhi metallo-β-lactamase-1.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.999 ml	14.997 ml	29.993 ml
5 mM	0.6 ml	2.999 ml	5.999 ml
10 mM	0.3 ml	1.5 ml	2.999 ml
50 mM	0.06 ml	0.3 ml	0.6 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Mcl1-IN-2