货号	规格	价格	上海	北京	珠海	重庆	武汉
S84802-2mg买3赠1	99.74%	￥340.00 S84802-2mg ￥340.00 现货（买3赠1）	5 5	-	-	-	-
S84802-5mg买3赠1	99.74%	￥460.00 S84802-5mg ￥460.00 现货（买3赠1）	10 10	-	-	-	-
S84802-10mg	≥99%	￥630.00 S84802-10mg ￥630.00 2-3天	0 货期：2-3天	-	-	-	-
S84802-25mg	≥99%	￥1200.00 S84802-25mg ￥1200.00 2-3天	0 货期：2-3天	-	-	-	-
S84802-50mg	≥99%	￥1800.00 S84802-50mg ￥1800.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Roflumilast N-oxide is a PDE type 4 inhibitor.

靶点：

PDE type 4;PDE

体内研究：

Single treatment of db/db mice with 10 mg/kg Roflumilast N-oxide enhances plasma glucagon-like peptide-1 (GLP-1) 4-fold. Chronic treatment of db/db mice with Roflumilast N-oxide at 3 mg/kg shows prevention of disease progression. Roflumilast-N-oxide abolishes the increase in blood glucose, reduces the increment in HbA1c by 50% and doubles fasted serum insulin compare with vehicle, concomitants with preservation of pancreatic islet morphology. Furthermore, Roflumilast-N-oxide amplifies forskolin-induced insulin release in primary islets. Roflumilast-N-oxide also shows stronger glucose-lowering effects than its parent compound

参考文献：

1. Victoni T, et al. Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells. Int Immunopharmacol. 2016 Jan;30:1-8. 2. Milara J,et al. Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro. COPD. 2015 Jun;12(3):320-31. 3. Vollert S, et al. The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice. Diabetologia. 2012 Oct;55(10):2779-2788.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.385 ml	11.927 ml	23.854 ml
5 mM	0.477 ml	2.385 ml	4.771 ml
10 mM	0.239 ml	1.193 ml	2.385 ml
50 mM	0.048 ml	0.239 ml	0.477 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

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Roflumilast N-Oxide