货号	规格	价格	上海	北京	珠海	重庆	武汉
S84804-5mg买3赠1	99.71%	￥300.00 S84804-5mg ￥300.00 现货（买3赠1）	1826 >10	-	-	-	-
S84804-25mg买3赠1	99.71%	￥660.00 S84804-25mg ￥660.00 现货（买3赠1）	373 >10	-	-	-	-
S84804-50mg买3赠1	99.71%	￥900.00 S84804-50mg ￥900.00 现货（买3赠1）	190 >10	-	-	-	-
S84804-250mg买3赠1	≥99%	￥3200.00 S84804-250mg ￥3200.00 现货（买3赠1）	36 >10	-	-	-	-

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产品描述：

Mequitazine is a potent, and long-acting histamine H1 antagonist.

靶点：

Histamine Receptor;HistamineReceptor

体内研究：

Mequitazine and clemizole antagonize the effect of histamine in guinea-pig ileum competitively. Mequitazine at 107 produces a parallel shift of the dose-response curve to acetylcholine in the rat duodenum. Mequitazine at highest concentration shows anticholinergic activity. Mequitazine inhibits contractile responses to KCl, phenylephrine (PE), 5-hydroxytryptamine (5-HT), and Ca2+ in rat aorta

参考文献：

1. Gonnot V, et al. Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate. Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1300-2. 2. El-Nakeeb MA, et a. In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates. Braz J Microbiol. 2011 Jul;42(3):980-91. 3. Martinez-Mir I, et al. Antihistaminic and anticholinergic activities of mequitazine in comparison with clemizole. J Pharm Pharmacol. 1988 Sep;40(9):655-6. 4. Satake N, et al. Possible mechanisms of vasoinhibitory effects of mequitazine, an antiallergic agent, on the contractions of isolated rat aorta induced by K+, phenylephrine, 5-hydroxytryptamine, and Ca2+. J Cardiovasc Pharmacol. 1994 Apr;23(4):669-73.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.101 ml	15.505 ml	31.011 ml
5 mM	0.62 ml	3.101 ml	6.202 ml
10 mM	0.31 ml	1.551 ml	3.101 ml
50 mM	0.062 ml	0.31 ml	0.62 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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