| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S84828-2mg买3赠1 |
≥98% | ￥280.00 |
货期：2-3天 | - | - | - | - |
|
S84828-5mg买3赠1 |
99.06% | ￥380.00 |
7 | - | - | - | - |
|
S84828-10mg买3赠1 |
99.06% | ￥624.00 |
1 | - | - | - | - |
|
S84828-25mg买3赠1 |
≥98% | ￥1250.00 |
货期：2-3天 | - | - | - | - |
|
S84828-50mg买3赠1 |
≥98% | ￥1730.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells[1] | ||||||||||||||||||||
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| 靶点： | Ki: less than 2 nM (FABP4), 250 nM (FABP3), 350 nM (FABP5);FABP | ||||||||||||||||||||
| 体内研究： | BMS-309403 sodium (15 mg/kg; chronic treatment; daily for 6 weeks) improves endothelial function, phosphorylated and total eNOS and reduced plasma triglyceride levels but did not affect endothelium-independent relaxations | ||||||||||||||||||||
| 参考文献： | 1. Sulsky R, et al. Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5. 2. Lin W, et al. BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase. PLoS One. 2012;7(8):e44570. 3. Lee MY, et al. Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol. 2011 Apr;162(7):1564-76. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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