货号	规格	价格	上海	北京	珠海	重庆	武汉
S84844-1mg买3赠1	98.30%	￥560.00 S84844-1mg ￥560.00 现货（买3赠1）	9 9	-	-	-	-
S84844-5mg买3赠1	98.30%	￥1780.00 S84844-5mg ￥1780.00 现货（买3赠1）	6 6	-	-	-	-
S84844-10mg买3赠1	98.30%	￥2720.00 S84844-10mg ￥2720.00 现货（买3赠1）	5 5	-	-	-	-
S84844-50mg	98.30%	￥6990.00 S84844-50mg ￥6990.00 现货	3 3	-	-	-	-
S84844-100mg	≥98%	￥9990.00 S84844-100mg ￥9990.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).

靶点：

Galanin-3 receptor;NeuropeptideYReceptor

体外研究：

HT-2157 (SNAP 37889) binds with high affinity to membranes from transiently transfected LMTK- cells expressing the human Gal3 receptor (Ki=17.44±0.01 nM; n>100) and is highly selective for Gal3 over the Gal1 and Gal2 subtypes (Ki>10,000 nM for each subtype; n=46 of each subtype). When tested for the antagonism of galanin-evoked inhibition of adenylyl cyclase, HT-2157 (0.1-10 μM) produces concentration-dependent rightward shifts of the concentration-effect curve to galanin

体内研究：

The galanin-3 receptor antagonist, HT-2157 (SNAP 37889), reduces operant responding for ethanol in alcohol-preferring rats. The novel selective GALR3 antagonist, HT-2157, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. Male iP rats treated with HT-2157 at a dose of 30 mg/kg (i.p.) do not show altered locomotor activity or changes in anxiety-like behaviour in the elevated plus maze or light-dark paradigms. Treatment with HT-2157 (30 mg/kg, i.p.) reduces operant responding for solutions containing ethanol, sucrose and saccharin. Collectively, results from the current study shows that HT-2157 (30 mg/kg, i.p.) is effective in reducing operant responding for ethan

参考文献：

1. Swanson CJ, et al. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94. 2. Ash BL, et al. The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats. Regul Pept. 2011 Jan 17;166(1-3):59-67.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.73 ml	13.649 ml	27.297 ml
5 mM	0.546 ml	2.73 ml	5.459 ml
10 mM	0.273 ml	1.365 ml	2.73 ml
50 mM	0.055 ml	0.273 ml	0.546 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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